Cycle on Jul 13, 2026

I will start this research cycle by listing the active threads for this topic to see if there are any outstanding questions, watches, or specific directives we need to monitor or resolve.

I will search for any recent news or regulatory decisions regarding gedatolisib (which has an upcoming PDUFA/regulatory decision watch scheduled for July 17, 2026). Since today is July 13, 2026, let's see if there are any early announcements or updates. I'll also do a broad search on recent major drug approvals, health policy, and science breakthroughs from the last week.

I see that gedatolisib's PDUFA date is indeed July 17, 2026, and the decision has not yet been announced (it is expected in 4 days). The articles from TechTimes and Medical Daily from the last few days describe the upcoming decision. Let's fetch the TechTimes article or Medical Daily article to get specific quotes and details on the Phase 3 trial (VIKTORIA-1) data and the patient population to prepare or update our understanding, though since the decision hasn't happened yet, we won't resolve the watch thread. Let's do a quick fetch of the TechTimes article.

I have excellent background on gedatolisib now. Since the decision is on July 17, 2026, and today is July 13, 2026, the watch `019f535e-c7d5-7317-939c-855999ccce9d` is not yet fired. I will keep it open. Now, let's search for other recent science and health news from the past week to see what major events have occurred. Let's look for FDA approvals, clinical trial readouts, disease outbreaks, or space/energy breakthroughs. Let's do a broad search of recent health, FDA, and science news.

These are major public health developments. 1. There is a massive, fast-growing **Ebola outbreak** in the Democratic Republic of Congo (DRC) that has been declared a Public Health Emergency of International Concern (PHEIC) by the WHO. The Washington Post, BBC, and other outlets are reporting on it today, July 13, 2026. This is highly consequential and fits our brief perfectly. 2. There is a major **Cyclospora parasite outbreak** in the US, largely concentrated in Michigan and Ohio, which has reached over 2,800 to 3,000 cases, possibly linked to lettuce/salad greens. Let's fetch the Washington Post or BBC article to get the details on the Ebola outbreak in the Democratic Republic of Congo. Let's do a search first to get the exact URL of the BBC or Washington Post article.

This is extremely significant. Key points: - This is the 17th Ebola outbreak in the DRC, caused by the **Bundibugyo** species (declared a PHEIC on May 17, 2026). - An Ebola treatment trial has just enrolled its first patients in the Ituri region of the DRC, testing two drugs in a program set up just six weeks after the outbreak was declared. - The death toll has surpassed 700, and confirmed cases are at 1,926 as of July 13, 2026. It has spread to two new provinces (Tshopo and Haut-Uele), making a total of at least four provinces. - We have an ongoing watch thread `019e99fb-4aa9-7dae-b1bb-e5b2ce833775` tracking the clinical trial initiation/readout for fast-tracked Bundibugyo Ebola vaccines (Moderna's mRNA, Oxford's ChAdOx1, and IAVI's rVSV). Let's see if this "record-breaking Ebola treatment trial" refers to therapeutic drugs (like monoclonal antibodies) or if there are also vaccine updates. Let's fetch the Guardian article `https://www.theguardian.com/global-development/2026/jul/12/record-breaking-ebola-treatment-trial-drc`.

This is a major development! - The **Partners treatment trial** has enrolled its first patients in the Ituri region of the DRC to test two drugs against the Bundibugyo species of Ebola: **remdesivir** (an intravenous antiviral by Gilead Sciences) and **MBP134** (a monoclonal antibody developed by Mapp Biopharmaceutical). - Another trial is scheduled to begin this week to evaluate **obeldesivir** (an oral antiviral, also by Gilead) as post-exposure prophylaxis to prevent contact cases from developing disease. - This is a historic, record-breaking pace: starting a therapeutic trial just six weeks after the WHO declared the outbreak a PHEIC on May 17, 2026. - As of July 13, 2026, the outbreak has surged to 1,926 cases and over 700 deaths (specifically 702 deaths). It has spread to four provinces in the DRC: Ituri, Tshopo, Haut-Uele, and another province (Bas-Uele or North Kivu). Let's do a search on the Cyclospora outbreak in the US to see if there's enough detail to write a brief finding, or if there's any other major news we should cover. Let's look up the Cyclospora outbreak first.

Let's fetch the CNN article `https://www.cnn.com/2026/07/13/health/cyclospora-parasite-diarrhea-outbreak-increase` to get the latest details about the Cyclospora outbreak. This is a massive domestic public health event with over 3,000 cases in Michigan and Ohio alone.

This is fantastic. We have two very strong, highly relevant, and recent stories that fit the "Latest" research mode perfectly: 1. **The DR Congo Ebola Outbreak & the Partners Treatment Trial**: The 17th Ebola outbreak in the DRC (Bundibugyo strain) has surpassed 700 deaths and 1,926 cases as of July 13, 2026, spreading to four provinces. Crucially, a record-breaking therapeutic trial (the Partners treatment trial) has enrolled its first patients just six weeks after the WHO declared a PHEIC on May 17, 2026. It is testing Gilead's antiviral remdesivir and Mapp Biopharmaceutical's monoclonal antibody MBP134. 2. **The Domestic Cyclospora Outbreak**: A massive summer outbreak of Cyclospora cayetanensis has sickened over 3,000 people in Michigan and Ohio alone (with 2,640 cases in Michigan as of July 13). Cases are reported in at least 31 states. Crucially, the tracking and trace-back of the outbreak are severely hampered by complex parasite genomics (unlike simple bacterial PCR/sequencing) and recent 2025 CDC funding/staff cuts that scaled back the FoodNet surveillance system. Let's check if there are other active threads we can resolve or if we should register new watches. The active thread `019f2f50-7f4d-7361-8f05-cdf170c2d727` targets H5N1 transmission in Australia to poultry or local wildlife. Let's do a quick search on Australia H5N1 just in case there is an update.

This is absolutely critical! - On **July 10, 2026** (just 3 days ago), Australia confirmed its **first H5N1 bird flu case in a native/local seabird** (a greater crested tern) and it is suspected in a seal. - This is a dramatic escalation because previously H5N1 was only detected in migratory birds (like skuas) on subantarctic islands or isolated coasts, but it has now reached a local Australian seabird and is spreading onto the mainland (South Australia and Western Australia). - The ongoing watch `019f2f50-7f4d-7361-8f05-cdf170c2d727` tracks whether the newly arrived H5N1 avian influenza strain jumps from migratory seabirds to local Australian wildlife, marine mammals (e.g. fur seals), or commercial poultry farms. - The trigger is: "Fires when Australia confirms the transmission of H5N1 to commercial poultry flocks, native land birds, or local marine mammal colonies." - It has indeed just been confirmed in a native land/local seabird (a greater crested tern) and is suspected in a seal! We should record this event! Let's fetch the Sydney Morning Herald (SMH) article to confirm the exact details of the local seabird and seal detection.

This is a very important development. We have confirmed: - On July 10, 2026, Australia confirmed its first H5N1 case in a **local/native bird**—a **greater crested tern** found at Robe on South Australia's Limestone Coast. This marks a transition from migratory subantarctic birds directly to local Australian wildlife. - This fires the watch `019f2f50-7f4d-7361-8f05-cdf170c2d727` ("Australia H5N1 transmission to poultry or local wildlife") since it has now officially transitioned to a local/native bird species! - However, since this watch is **ongoing** (as it tracks further jumps to poultry or marine mammal colonies), we should record the event but keep the watch open (`resolves: false`). Let's record the event on that thread now.

Now let's write three notes: 1. One on the **DR Congo Ebola Outbreak & Partners Treatment Trial**. 2. One on the **U.S. Cyclospora Parasite Outbreak**. 3. One updating the **Australia H5N1 Bird Flu** situation. Let's check if there are any existing notes on Australia H5N1 or Ebola to reuse slugs. I'll read the notes for this topic.

I see that we have existing notes: - `bundibugyo-ebola-outbreak-drc-uganda` is the existing note for the Ebola outbreak. We should reuse this slug to update it with the record-setting trial enrollment (Partners trial) and the updated case counts (1,926 cases, 702 deaths). - `cyclosporiasis-michigan-multistate-outbreak-2026` is the existing note for the Cyclospora outbreak. We should reuse this slug to update it with the jump to over 3,000 cases and the details regarding the tracking hurdles due to CDC cuts and parasite genetics. - `australia-h5n1-wildlife-transmission` is the existing note for the Australia H5N1 mainland transition (confirmed on July 10). We should reuse this slug to update it with the greater crested tern details and the fur seal testing negative. Let's write these three notes. No other new findings are needed. Let's make sure our notes are perfectly detailed, carry verbatim quotes with links, and reuse these exact slugs. First, let's write the updated note for the Bundibugyo Ebola outbreak.

Now, let's write the updated note for the domestic Cyclospora outbreak using the slug `cyclosporiasis-michigan-multistate-outbreak-2026`. This note will detail the jump past 3,000 cases, the genetic complexity of tracing the parasite, and the impact of CDC's 2025 FoodNet surveillance cuts.

Now, let's write the third note updating the Australia H5N1 bird flu situation using the slug `australia-h5n1-wildlife-transmission`. This note will detail the confirmation of the first case in a local/native seabird (the greater crested tern in South Australia) and the negative test result of the suspected fur seal on the NSW Central Coast.

I have successfully written and updated the three crucial findings for this cycle: 1. **Bundibugyo Ebola Outbreak & Partners Trial**: Updated with the record-setting Partners treatment trial enrolling its first patients and the latest case counts of 1,926 cases and 702 deaths. 2. **U.S. Cyclospora Parasite Outbreak**: Updated with the surge past 3,000 cases in Michigan/Ohio and details on how CDC's 2025 FoodNet surveillance cuts and the genetic complexity of the parasite hamper trace-back. 3. **Australia H5N1 Bird Flu**: Updated with the first local native bird detection (greater crested tern) on the Australian mainland and the negative fur seal test in NSW. I also successfully recorded the event on the ongoing watch thread for Australia's H5N1 wildlife transmission (`019f2f50-7f4d-7361-8f05-cdf170c2d727`), keeping it open as the situation continues to develop. I will now call `finish_cycle` to complete this research cycle.

I have successfully completed the research cycle. All findings have been updated with the latest primary evidence, and the relevant watch thread event has been recorded.